Dr. Wisco is the Director of the Laboratory for Translational Anatomy of Degenerative Diseases and Developmental Disorders. In general, the lab is interested in the anatomical validation of innovative neuroimaging and surgical techniques. Specifically, the lab focuses on the histological validation of Alzheimer's disease imaging biomarkers, and of Diffusion Tensor Imaging tractography, both in human and mouse brains. In addition, the lab is part of two multi-institutional collaborations to characterize stellate ganglion innervation of cardiac tissue to inform the effects of stellectomy surgery; and to validate a new surgical procedure to use phrenic nerve roots to restore laryngeal function after recurrent laryngeal nerve denervation. The lab also maps the 3D organization of skeletal muscle fibers and distribution of extrafusal and intrafusal peripheral nerve fibers associated with the major synovial joints.
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